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History of PGT-A The history of PGT-A all starts with the idea that chromosomal aneuploidy is the main reason embryos fail to implant or miscarry. 65% of abnormal embryos end in spontaneous miscarriages. I can't thank you enough, I really needed to find this post. I am concerned something bigger is going on as I was diagnosed with weird autoimmune things at age 40 plus (same time I started to miscarry)- i.e. Have you ever heard of someone to have a healthy pregnancy after miscarrying a PGS tested embryo? After a second, similar m/c I saw a recurrent pregnancy loss specialist, and she ordered tests to be run on the "products of conception" (such an grim, awful term) from both m/c. Studies of PGS on Day 5 do show improved implantation rates and decreased miscarriage rates. Natural FETs can start with your next cycle and don't have BCPs involved. Successful haematopoietic stem cell transplantation in 44 children from healthy siblings conceived after preimplantation HLA matching. But there is an emotional cost of experiencing a miscarriage. Using PGT-A to improve live birth rates in IVF when the technology isnt specifically indicated is controversial. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Hopefully we are in that group! KellyLeigh & others, I'm very sorry to hear about your losses. So I am assuming I am going to follow the standard protocol that I did last time since I did achieve pregnancy, but this still makes me feel a bit uneasy since it ended in a miscarriage. Chemical pregnancy with PGS tested embryo - Infertility - Inspire Before you decide, make sure you understand why your doctor recommends this assisted reproductive technology for you, the total costs (including cryopreservation and FET cycles), and the potential risks. Sevenpips, what is your plan moving forward? Some studies find a benefit, and some don't. Does PGS testing increase success rates? Im very sorry youre going through this. Whether PGT-M/PGT-A can truly improve live birth rates beyond these situations is unclear. The RPL specialist found nothing out of the ordinary, so my losses remain totally unexplained. Both PGT-M and PGT-A take placeduring preimplantation, before the embryo has implanted in the uterus. I am in the process of doing iVF with PGS for the first time due to multiple miscarriages. MC is never easy and when it's a pgs normal embryo it just doesnt seem to make sense.