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To what degree CK spikes depends on the type and duration of exercise [8, 13, 14, 15]. A study of over 700 athletes suggests that normal reference ranges for athletes may be over two times higher than normal ranges: 82 1,083 U/L in men and 47 513 U/L in women [12]. Most laboratories use the central 95% of observations in white individuals as a reference vary for serum CK, assuming that ranges have a gaussian (bell-shaped) distribution, which is normally about 0 to 200 IU/L. In two studies with over 1.8k patients each, critically ill and chronic kidney disease patients with low creatine kinase levels had higher mortality rates [93, 94]. $MMT = window.$MMT || {}; $MMT.cmd = $MMT.cmd || [];$MMT.cmd.push(function(){ $MMT.display.slots.push(["e023039a-a41d-404b-ba77-d0a561240f4b"]); }). Glomerulonephritis. $MMT = window.$MMT || {}; $MMT.cmd = $MMT.cmd || [];$MMT.cmd.push(function(){ $MMT.display.slots.push(["bf84ea07-bd33-4824-bab3-02410772e6f3"]); }). Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2019. Awdishu L, et al. An elevated level of creatine kinase is seen in heart attacks, when the heart muscle is damaged, or in conditions that produce damage to the skeletal muscles or brain. Serum creatine kinase (CK) levels are higher after eccentric, muscle-damaging exercise in statin-treated patients. A small study with 14 men showed that sports massage 2 hours after exercise decrease CK levels [83]. Its a good idea to avoid physical activity before getting a CK test. Your body produces the enzyme creatine kinase or creatine phosphokinase to keep your muscles functioning properly. 2023 Johns Hopkins Arthritis CenterPatient Privacy, RheumTV Patient Education Video Library, The Camille Julia Morgan Arthritis Research and Education Fund, Disease Modifying Antirheumatic Drugs (DMARDs), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Johns Hopkins Lyme Disease Research Center. Examples can include things such as dehydration or intake of large amounts of protein or the supplement creatine. However, it could also be caused by a neuromuscular, metabolic, or rheumatologic condition, like arthritis or lupus. vitamin d Insufficient Evidence Answer. Healthcare providers order CK tests to check for muscle damage caused by diseases and injuries. Your doctor will work with you to evaluate your symptoms and determine the treatment thats right for you. Creatinine test. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. What seems to be an elevated CK stage might in truth be regular, and it is very important decide within the preliminary evaluation whether or not a CK worth is really irregular. UpToDate A recent study found that some coffee drinkers were 20% less likely to develop melanoma. In a study of 1,444 subjects, higher CK levels were linked with higher BMI and waist-to-hip ratio [18]. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This could contribute to the increased statin Very strenuous exercise and consuming large amounts of Also, people who are untrained will experience greater spikes in CK levels due to greater muscle damage [8]. NCI CPTC Antibody Characterization Program. what supplements can cause high ck levels - TheFitnessManual Creatinine levels may vary due to factors like by age, sex, race, hydration, or body mass. Exercises that involve weightlifting and downhill running cause higher increase in CPK levels.