Blurred Money Prop, Man Killed In Far Rockaway Today, Eakes Funeral Home Oxford Nc, Articles T

Klouda T, Hao Y, Kim H, Kim J, Olejnik J, Hume AJ, et al. Acta Pharmacol Sin 44, 695709 (2023). Zhang FS, He QZ, Qin CH, Little PJ, Weng JP, Xu SW. 2020;11:70722. Persisting olfactory dysfunction in post-COVID-19 is associated - PLOS 2021;12:653110. Recent randomized clinical trials revealed that treatment with fluvoxamine (a selective serotonin reuptake inhibitors, SSRI) reduced the need for COVID-19 hospitalization, reduced mortality and improved outcome over 15 days [148,149,150]. Ilonzo N, Judelson D, Al-Jundi W, Etkin Y, OBanion LA, Rivera A, et al. 2022; 2090792. https://doi.org/10.1080/21688370.2022.2090792. All these reported effects could justify the curative effects of tocilizumab on COVID-19 [138]. It remains to be investigated whether other mechanisms that are more closely related to COVID-19, such as long non-coding RNA, circular RNA, RNA methylation, microbiota and metabolites, are involved in triggering endothelial dysfunction following SARS-COV-2 infection. Onorato D, Pucci M, Carpene G, Henry BM, Sanchis-Gomar F, Lippi G. Protective effects of statins administration in European and North American patients infected with COVID-19: a meta-analysis. 2021;2021:8671713. Clin (Sao Paulo, Braz). Google Scholar. 2. Biomedicines. PubMed Ashour L. Roles of the ACE/Ang II/AT1R pathway, cytokine release, and alteration of tight junctions in COVID-19 pathogenesis. Endothelial integrity is essential for maintaining the pulmonary capillary-alveolar barrier and lung homoeostasis. Direct or indirect mechanism after SARS-CoV-2 infection and the consequent endotheliitis/endotheliopathy incites multiple instances of endothelial dysfunction, including altered vascular tone, oxidative stress, inflammation/leukocyte adhesion, endothelial mesenchymal transition (EndoMT), mitochondria dysfunction, virus-induced senescence, cytokine storm, and coagulopathy [12, 13]. 2020;7:559811. Pharmacol Res.