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Ekstedt M, Franzn LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, Kechagias S: Long-term follow-up of patients with NAFLD and elevated liver enzymes. This article will discuss the symptoms, causes, diagnosis, and treatment of NASH. Since many medications can harm your liver, always let all your health care providers know about any medications you are taking. It is quite common with up to 25% of people in the world having this condition. As in other studies it is a challenge to classify patients into non-alcoholic and alcoholic group. INR (international normalized ratio). Int J Mol Sci. And when this happens, scar tissue forms. It must be stressed that the indications for the liver biopsy was not always clear, although most cases were because of elevated liver function tests and/or hepatomegaly or suspected alcoholic liver disease, and this in turn can give a selection bias. Differences between groups were investigated by Wald test in Cox proportional hazards model, with age as the time-scale, adjusting for gender, calendar year of diagnosis and age of diagnosis. Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital of Iceland, Hringbraut 11D, 101, Reykjavik, Iceland, Svanhildur Haflidadottir&Einar S Bjrnsson, Department of Pathology, The National University Hospital, Reykjavk, Iceland, Faculty of Medicine, University of Iceland, Reykjavk, Iceland, Jon G Jonasson,Helga Norland,Sigrun H Lund&Einar S Bjrnsson, Laboratory of Pathology, NIH/NCI, Bethesda, MD, USA, Centre of Public Health, University of Iceland, Reykjavk, Iceland, You can also search for this author in Even generic drugs like acetaminophen, the generic ingredient in Tylenol and some cold medicines, may be harmful if you take too much for too long, especially if you have liver disease or drink alcohol heavily. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, Everything you need to know about cirrhosis, What to know about liver failure and liver disease stages, Diet for jaundice: What to eat for a healthy liver. The Lancet. NASH may present with no symptoms, or the symptoms may go unnoticed, which makes this a hard condition to diagnose. Liver cirrhosis is a condition characterized by liver scarring, impaired liver function, and other side effects. The fact that patients with AFLD did not differ with respect to BMI and incidence of metabolic syndrome-related diseases might reflect a mixed AFLD/NAFLD etiology in the alcoholic group. Funding Acknowledgement: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute. Nonalcoholic fatty liver disease (NAFLD) is a condition in which fat builds up in your liver.The more severe form of NAFLD is called nonalcoholic steatohepatitis (NASH).NASH causes the liver to swell and become damaged.