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Koo S-H, Satoh H, Herzig S, et al. Before As shown in Figure 6, HK II protein expression was decreased in kidney of HFD group mice compared with LFD group mice; however, it was almost back to normal level by BL153 administration at indicated doses (Figure 6). Kim YJ, Choi MS, Cha BY, et al. In THP-1 cells, magnolol and honokiol reduced inflammatory TNF- and IL-8 production induced by Propionibacterium acnes (3). Furthermore, in vivo study indicated that honokiol, another compound isolated from the Magnolia herb, modulated inflammation-associated cytokines, such as interleukin-1, interleukin-6, TNF-, and monocyte chemoattractant protein-1, through activation of NF-B [24]. They have also been evaluated for their anticancer potential. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis. Magnolia bark extract is readily available in pill form. A chemical in magnolia reduced damage in the. MG132 is a peptide aldehyde proteasome inhibitor and exerts its therapeutic effects by reducing the degradation of ubiquitin-conjugated proteins such as nuclear-factor-E2-related-factor-2 (Nrf2), an important transcription factor regulating cellular defenses against reactive oxygen species, through inhibiting activity of the subunits of the core particle of 26S proteasome [38]. Pendergrass M, Koval J, Vogt C, et al. The disease is most active during the warm summer months. A proposed mechanism by which BL153 attenuates kidney damage during obesity is illustrated. For example, 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, prevents the development and progression of Alzheimer's disease by improving oxidative stress through a p38 MAPK-dependent pathway [25]. Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of. My HWP has magnolia bark combined with PEA for pain in a . Magnolia Bark: How Can It Improve Your Overall Health - WebMD Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Kidney tissue was fixed overnight in 10% phosphate-buffered formalin and then dehydrated in a graded alcohol series, cleared with xylene, embedded in paraffin, and sectioned at 5m thickness for pathological staining. Animal studies show the anti-inflammatory and antioxidant properties of magnolia bark protect kidneys from high-fat diet-induced damage. 2008 Apr 1;32(3):715-25. doi: 10.1016/j.pnpbp.2007.11.020. If the disease has affected the branch, cut it off a little closer to the trunk. In addition, some research -- in humans and animals -- suggests magnolia may also be useful in these ways: Some research has suggested some other possible benefits for magnolia: It might also help treat or prevent: Supplement makers may suggest varying amounts of their product for different purposes. Throw away any damaged leaves far away from the yard. Taking magnolia bark along with drugs that promote sleep or treat anxiety, such as sedatives, sleep medications, and barbiturates, may cause drowsiness.