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Duplication for commercial use must be authorized by ASHP. Resources It can cause symptoms such as: You may also have other symptoms, depending on the specific type of interstitial lung disease you have. We comply with the HONcode standard for trustworthy health information. government site. You should stop smoking before you start taking nintedanib and avoid smoking during your treatment. Anti-fibrotic therapy in the treatment of IPF: Ongoing concerns and Instead, it helps reduce new scarring. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). As long as you are tolerating nintedanib, and it is still slowing your condition's progression, you can keep taking it. If recommended by your doctor, you may be able to receive a 90-day supply of Ofev, so theres less concern about running out of the medication. PDF Nintedanib - patient information - UHS Ofev: Uses, Dosage & Side Effects - Drugs.com Call your doctor for medical advice about side effects. If you use hormonal birth control (birth control pills, injections, implants, skin patches, or vaginal rings), also use a barrier form of birth control to prevent pregnancy while taking Ofev. To help make sure that you dont miss a dose, try using a medication reminder. TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: The most common side effects of Ofev are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure. from 8 AM - 9 PM ET. If you and your doctor determine that Ofev is safe and effective for you, youll likely take it long term. Your doctor will order certain lab tests before and during your treatment to check your body's response to nintedanib. They also may be able to recommend tools that can make it simpler to open lids. If you drink alcohol, talk with your doctor about how much (if any) is safe to drink while taking Ofev. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. The drugs mirrored each other in the number of phase III clinical trials leading to approval and slowing of forced vital capacity (FVC) decline, with pirfenidone touting a signal for improved mortality, and nintedanib suggesting decreased incidence of acute exacerbation in two of its three large trials. You take trametinib only once a day. To find out how often side effects occurred in clinical trials, see the prescribing information for Ofev. Tyrosine kinases play an important role in cell growth, differentiation, and metabolism and there is substantial evidence that certain tyrosine kinases, notably platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR), as well as non-receptor tyrosine kinases, are associated with scar tissue and the progression of pulmonary fibrosis and other interstitial lung diseases.