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Both false-positive and false-negative test result possibility is depicted in each test type. Surkova E, Nikolayevskyy V, Drobniewski F. False-positive COVID-19 results: hidden problems and costs, Designs, formats and applications of lateral flow assay: a literature review, Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays COVID-19: laboratory and diagnosis, Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection, Role of citrate and NaBr at the surface of colloidal gold nanoparticles during functionalization, Effects of temperature and relative humidity on the stability of paper-immobilized antibodies. Furthermore, SARS-CoV-2 may not be detected, or may give rise to ambiguous test results, if the genome expressing target genes is mutated [2]. A new study demonstrates that testing of oropharyngeal secretions may reduce the number of false negative results from nasal swab testing of patients who have seemingly recovered from the disease. Nasal Sprays Could Protect You From Serious COVID-19 Illness When it comes to the claim that a nasal spray or Neti Pot could affect your COVID test -- there is no definitive answer because it depends on which type of test you use and -- more research is needed. Clinical trials will be necessary to establish the drugs effectiveness in prevention, early treatment and as a secondary therapy for severe COVID-19. Boukli N, Le Mene M, Schnuriger A, et al. Expert opinion: The diagnostic accuracy and the capacity of every available assay, which need to be interpreted in the light of the background incidence of SARS-CoV-2 infection in the communities in which they are used, are essential in order to minimize the number of falsely tested cases. Figueiredo-Campos P, Blankenhaus B, Mota C, et al. Sensitivity of both nucleic acid tests and antibody tests is affected by number of variables. LFIAs may be susceptible to temperature fluctuations, humidity, and positioning of the cassette during the testing procedure [11,12]. "Most tests should be able to still detect the virus because they should have such a high specificity or a high detection rate in the actual way that the test was built, explained Dr. Shepherd. Fernndez F, Gutirrez J, Sorlzano A, et al. Now, rapid tests are widely available. Depending on which type of COVID-19 test you get and where you get it done, you may get your results anywhere from several minutes to a week or more. Laboratory tests are characterized by their ability to detect a positive case (sensitivity) and their ability to determine a negative case (specificity). Rapid testing has become a popular tool in the coronavirus pandemic, especially during the initial Omicron wave in 2021. A negative result using at-home COVID-19 antigen test means the test did not detect the virus that causes COVID-19, but it does not rule out COVID-19 because some tests may not detect the virus . This review article has summarized what is currently known about false-negative and false-positive tests for SARS-CoV-2, and clinical scenarios that may give rise to such erroneous results. Comparison of the SYBR green and the hybridization probe format for real-time PCR detection of HHV-6, Comparison of different probe-level analysis techniques for oligonucleotide microarrays. Wang et al reported false-positive SARS-CoV-2 antibody tests in the face of rheumatoid factor, while Tan et al described possible cross-reactivity with HIV [21,22].