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2018 Oct 1;17(10):1092-1098. Emily C. Murphy, BS1,2 and Adam J. Friedman, MD1, 1The George Washington University School of Medicine and Health Sciences, Washington, DC, USA 2Georgetown University School of Medicine, Washington, DC, USA. The https:// ensures that you are connecting to the Epub 2018 Jun 1. MeSH Eskata: Hydrogen Peroxide Solution for SKs | RealSelf Hydrogen Peroxide 40% Monograph for Professionals - Drugs.com [22], Seborrheic keratoses have a dull, waxy, verrucous, stuck on appearance. A: Thank you for bringing this research to our attention. Post hoc, the authors also calculated the mean per-patient percentage of clear/nearly clear SKs, which was higher for HP40 than vehicle (47%, 54% versus 10%, 5%, respectively).20, To examine the efficacy of HP40 by location, the percentage of clear/nearly clear SKs at day 106 for each anatomic site was calculated in another study.22 A total of 1,868 SKs were treated in the HP40 group and 1,880 SKs were treated in the vehicle group; 59% of SKs were on the trunk, 30% on the face, and 11% on the extremities. [9] Recently, topical hydrogen peroxide solution was FDA approved for the treatment of seborrheic keratosis. Spanish. 2017 Nov 1; [PubMed PMID: 29141054], DuBois JC,Jarratt M,Beger BB,Bradshaw M,Powala CV,Shanler SD, A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. Sayan A, Sindel A, Ethunandan M, et al. DuBois JC, Jarratt M, Beger BB, et al. Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis. A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. Pedunculated SKs or SKs in intertriginous areas, hair-bearing areas, or within 5 mm of the orbital rim were excluded. When choosing a strategy for SK removal, it is important to consider the SKs location as well as the patients skin type and treatment expectations. Overlapping lesions or high numbers ofseborrheic keratosis can make the diagnosis and workup of these lesions more difficult. Classification of the seborrheic keratosis. Dermatoscope findings forseborrheic keratosis generally show milia cysts, comedo-like openings, fissures, and ridges. Additionally, this treatment method does not permit any histologic confirmation of the lesion and should only be for low-risk, low clinical suspicion for malignancy. Federal government websites often end in .gov or .mil. If concerning features are present, such as ulcerated lesions or rapidly changing lesions, a dermatoscope and skin biopsy allow for further classification. Hydrogen Peroxide 40% (Eskata) for Seborrheic Keratosis Existing keratolytics (ammonium lactate, imiquimod, and tazarotene) and vitamin D analogs were examined to treat SKs, but these agents demonstrated limited efficacy in small clinical trials.16-19, The first topical therapy to be US FDA-approved for the treatment of raised SKs is HP40 (Eskata), a stabilized topical solution of 40% hydrogen peroxide (H2O2).20 This therapy was approved in December 2017 based on the results of two phase 3 trials.20 An earlier phase 2 dose-ranging trial additionally confirmed that HP40 was more efficacious than 32% H2O2 while still having a satisfactory side effect profile.21, In this review, we will discuss the evidence for and limitations of HP40 based on these clinical trials as well as an ex vivo model of Fitzpatrick Skin Type (FST) V skin that examined HP40s cytotoxicity.20,22,23.